Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
SETTING: This house is in Kenwood, a neighborhood of 19th- and 20th-century Tudors, Mediterraneans, Victorians and colonial-style houses between Cedar Lake and Lake of the Isles, in the city’s Chain of Lakes. Roads are curving; sidewalks are lined with maple and ash trees. According to the listing agent, many of the neighborhood’s older houses have been restored, while houses built within the last 30 years have been torn down and replaced.
Movie buffs will soon be able to celebrate with a visual feast at the Beijing International Film Festival, where nearly 500 high quality films will be shown.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The 2014 ranking of 100 programmes for working senior executives is headed by Trium, runby HEC Paris, the London School of Economics and Stern School of Business at New York University. The top five places continue to be dominated by intercontinental EMBAs.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
It's a tall order, but if you want to go after one of the thousands of supply-chain jobs that are going begging, a solid start would be logistics training, available at many colleges and universities. Some programs, like Penn State's graduate certificate in supply chain management, are offered online.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The estimates include earnings from movies, TV and endorsements from cosmetic and other companies. Bollywood star Deepika Padukone is the only newcomer on the list.
Trends and targets in antiviral phototherapy
5.You Aren't Making Enough Money to Pay Your Bills
7. Your company's human resources staff saw your résumé on a job board。
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
The 54-year-old has already said he wants Bain to be recognised as a go-to provider of digital expertise. The question is whether this will be achieved through acquisitions, poaching teams or retraining the existing workforce.
The next step? Jalava plans to upgrade the finger with an RFID tag and add wireless support. He also wants to add more memory, which seems pointless to us. If he needs more storage, he has nine other fingers he can chop off and replace with flash drives.
ACE2 as a potential therapeutic target for pandemic COVID-19
I want to be in your arms this New Year.我要在你的怀抱里度过今年的春节。
The cart-topper's latest track, There's Nothing Holdin' Me Back, saw him beat out the likes of DJ Khaled 's Wild Thoughts ft. Rihanna, as well as Ed Sheeran's smash hit, Shape of You. and Daddy Yankee & Luis Fonsi's record-breaking Despacito.
Diagnostic technologies for COVID-19: a review
The study was based on 3,095 questionnaires from 2016 graduates and 1,661 questionnaires from employers across the country.
6.You Spend Time Looking For Other Jobs
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
The bulk was due to underlying global warming caused largely by rising emissions of carbon dioxide, the main man-made greenhouse gas produced by burning fossil fuels, such as coal and oil.
'People go crazy and it gets overwhelming.'
Harvard topped the league table, followed by Massachusetts Institute of Technology and Stanford University.
Golden State righted itself over the next few months. Kevin Durant suffered an injury which let Stephen Curry be Stephen Curry again, and when Kevin Durant returned, the team had found a balance between their two MVPs. The result was a terrifying burst through the playoffs, as the Warriors swept the Western Conference playoffs. Portland offered no resistance. Utah put up a noble effort but still couldn't get a game. The Spurs led by 20 ... and then Kawhi Leonard went down with an injurywhen Zaza Pachulia stuck his foot out, and that was that.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
The report shows that social media, and especially WeChat, has become more and more popular in the past year among people over the age of 40.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
In 2016, we've seen a whole lot of new gadgets join the Internet of Things (unfortunately, we've also seen them harnessed by hackers to bring downhuge swaths of the internet). From appliances to clothing, companies really want to sell you the tech that'll make your life "smarter," but sometimes it just makes it slower and dumber. Let's look back on some of the most ridiculous and useless internet-connected gadgets that were produced in the past 12 months.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
The Great Recession had devastating effects across the U.S. and few places were as hard hit as Arizona. The state was booming on the strength of its tourism and real estate markets during the 2000s. Median home prices jumped 70% between 2003 and 2006—only Nevada had bigger gains—fueling more building and construction jobs. Monthly unemployment was at 3.5% through much of 2007. But then the bottom fell out. Home prices plummeted more than 50% from their peak and 6% Arizona properties received foreclosure filings in 2009. Unemployment stubbornly remained in double-figures for most of 2009 and 2010 and only Nevada lost a higher percentage of jobs over the last five years. Household incomes declined at the fastest rate in the country since 2008.
Antiviral drug discovery: broad-spectrum drugs from nature
This is the 16th edition of the FT global executive MBA ranking.
Influenza neuraminidase: A druggable target for natural products
“世界各地的政策制定者认识到美联储的决定将产生什么影响，为此忧心忡忡，这让我们担心，”百达资产管理公司(Pictet Asset Management)全球新兴债券部门主管Simon Lue-Fong表示。“人们在说美联储的决定已被反映到价格上，但既然没人知道究竟会发生什么，这怎么可能呢。”
The Harry Potter star Emma Watson hold fifth position in the list of ten most beautiful women of 2015. The English actress, model, and activist, Watson took the top spot on the AskMen “Top 99 Outstanding Women 2015″ list and at number 26 on the TIME 100 list of the world's most influential people.
Have a love filled New Year!
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
7. 《教师》(The Kindergarten Teacher)。在这部严酷、怪异的轰动之作中，以色列导演那达夫·拉皮德(Nadav Lapid)讲述一个教师对一个儿童诗人的迷恋，为狂热及其代价绘制了一幅残忍的肖像。
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Migrants working in rich countries sent home almost half a trillion dollars in 2016, helping to lift families out of poverty by providing financial stability, access to education, housing and healthcare, according to a global report.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
While Insead’s joint programme dropped back into second place, its single-school programme moved up three places to fourth, a place it last occupied in 2011.
The eighth grader's candidacy is also about overcoming age discrimination, which he sees as a barrier to equality, and he says his quest for the top state spot is no joke.
n. 沼地，极多，回转 n. 大量，许多 v. 使转，扭
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Farewell to Cassini
Nicole Kidman had daughter Sunday Rose at age 40, with her husband, the country singer Keith Urban. 妮可·基德曼40岁时和其丈夫，乡村歌手凯斯·厄本生下女儿桑迪·
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
当芬兰程序员Jerry Jalava 2008年遇到车祸，他面临双重悲剧。首先，他失去了他的手指，对于靠打字生存的人来说是个大问题。其次，他必须跟一个幽默感过剩的医疗小组打交道。了解了他的遭遇后，一位外科医生竟然提议Jalava应该出门去买个“USB手指驱动器”。
Inhibition of SARS coronavirus helicase by bismuth complexes
The American share in the total drugspending is about one third. IMS experts estimate that in 2014 it will rise11.7 percent. The UShas particularly high prices, according to the report, but drug makers defendthis by citing the soaring cost of new medicine development.
To Anita Eerland and Rolf Zwaan [THE NETHERLANDS] and Tulio Guadalupe [PERU, RUSSIA, and THE NETHERLANDS] for their study “Leaning to the Left Makes the Eiffel Tower Seem Smaller."
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Volatility in currency markets is also likely to be a factor for agricultural commodity prices in the next 12 months, with the euro likely to depreciate as a result of French, Dutch and German elections, Rabobank reckons.
While the FT online and full-time MBAs are not strictly comparable because the criteria used to judge them are slightly different, it is interesting to note that IE and Warwick Business School are among six schools to feature in both rankings.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
“An employee sent his boss a text message to say he was leaving.”
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Subdivided flats smaller than 100 square feet (9 square meters) can rent for $385 in the Asian city.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
The killer combo of Judi Dench and Stephen Frears team up again, four years on from Philomena, with a Lee Hall-scripted look at the friendship between Queen Vic and a young Indian clerk. Eddie Izzard looks like inspired casting as Bertie, the Prince of Wales; filling out the rest of the cast are Olivia Williams, Tim Pigott-Smith and, once again, Simon Callow and Michael Gambon.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
I hope you have a most happy and prosperous New Year.
Likewise, if the 11 countries led by Japan left in the TPP manage to salvage a deal following the US exit that could provide some balance in the region.
Manufacturing has held up better, with profits growing 6.5 per cent, while profits from utilities such as electricity, heat and water grew 17 per cent, boosted by lower energy prices.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The China Association of Automobile Manufacturers announced on Friday that passenger car sales totaled 2.2 million units in January, 9.3 percent more than a year earlier, and the production of new-energy vehicles surged by 144 percent.
2013 Rank: 2
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Wang Chunfa, executive secretary of the China Association for Science and Technology, has expressed deep concern over the retraction, which came just days after he met in Beijing with Arnout Jacobs, the head of Springer Nature for Greater China.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
On Tuesday, 17-year-old Thomas Sohmers unveiled a new super fast computer server that uses a fraction of the electricity that a normal computer does.He's showing it off at the Open Compute Project (OCP) Summit happening this week in San Francisco.This computer is the first product from Sohmers' startup, REX Computing, created with 52-year-old co-founder and CTO Kurt Keville.
Justin Bieber剃发募捐 集得4万美金
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
If a sitcom that lasts for 10 years is considered popular, then surely one that still stirs up emotions after 20 must be considered a classic. Friends first aired in the US in 1994, featuring a cast of six young men and women in New York. In the time since, it’s become one of the most famous titles in the sitcom genre, aired in over 100 countries and regions in the world.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Mr. Sissako is both an indispensable political filmmaker and one of the great poets of contemporary cinema. His portrait of life under jihadi rule in northern Mali is brutal and shocking, but also gentle, generous and surprisingly funny. Mr. Sissako does not humanize violent extremists so much as demonstrate that they already belong to the species and reflect part of our common, tragic nature. But his movie also insists that the only effective and ethically serious way to oppose fanaticism is with humanism. Which is to say with irony, with decency and, perhaps above all, with art. (Read the review.)
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
n. 感动(激动，愤怒或震动), 搅拌，骚乱
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
With 10 guesses, an attacker would have a 39% chance of guessing Korean-speaking users' answers to the question "What is your city of birth?"
And the public chose Callabro to be crowned this year's winner, where they will take home a ￡250,000 cash prize and a spot at this year's Royal Variety Performance.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
Lady Gaga以5.9千万位列第四，其后是5.45千万的碧昂斯。前者在统计期间演出了66场，也靠与范思哲和MAC的合约获得收入，同时还有她自己的黑色香水。后者与其老公Jay Z的On The Run巡回演唱会通过19天（北美日期），赚得了超过10千万，创造了能与滚石相比较的第一对音乐界夫妻档夜平均的神话。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
The North has already warned that Park will "pay for his crimes in blood" if copies of the film make it across the border.
Happy new year, my best friend.祝我的挚友新年快乐。
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
According to the Chinese Academy of Social Sciences, China's migrant workers account for around 50 percent of the labor force in industrial and related sectors. Yet they don't enjoy equal rights as city dwellers because of household registration requirements.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
There’s nothing worse than a boss who says one thing and does another, and nothing better than one who keeps his word. Just as managers must trust their team, employees must trust their boss to have their best interests at heart。
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Were you late to work yesterday because you couldn't remember where you put your car keys? Did you completely forget about a coffee date last week with a friend and only remember when you got a text asking, "where are you?" Can you no longer remember the name of your favorite elementary school teacher? Memory problems impact just about everyone to a certain degree, but science suggests you might be able to improve your memory, as well as reduce the likelihood of Alzheimer's and dementia, by engaging in certain activities, eating specific foods, and using certain mnemonic devices.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
“The employee submitted a message through the company web site.”
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Loyal employees of this auto services company are rewarded on their 10th anniversary -- and every five years after --with a weekend getaway at a resort in Boca Raton, Fla. (The company is headquartered just 15 minutes away.)
It's impossible to list every woman who's ever existed, this list obviously be restricted to women who've achieved a fair level of celebrity. These are the hottest women celebrities of 2015.
节目8 创意儿童节目《剪花花》，邓鸣贺 邓鸣璐、中国舞蹈家协会南方舞蹈学校
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
I'm only a child yet I know if all the money spent on war was spent on ending poverty and finding environmental answers, what a wonderful place this earth would be! 我只是一个小孩，然而我知道，要是把花在战争上的钱，用在找寻环境问题答案上来，或用在结束贫穷并找到解决的方案上来，这个星球将是个多么美好的地方啊！
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Rossi, 31, spends his days calculating the future costs of the Pentagon's pension, health and education benefits, but says his job involves more than just crunching numbers for spreadsheets. He communicates with other government agencies and brainstorms with colleagues about financial models.
10. Run the Jewels “Run the Jewels 2” (Mass Appeal) Speaking of urgent and stinging, Killer Mike and El-P, veteran underground rappers from different scenes, found firm traction on their second round as Run the Jewels. Their flow is strong and their focus is furious on an album that calls out power structures but lets nobody off the hook.
The new numbers, reported by a tracking initiative called the Global Carbon Project and published in the journal Nature Geoscience, came on the eve of a United Nations summit meeting meant to harness fresh political ambition in tackling climate change. Scientists said the figures showed that vastly greater efforts would be needed to get long-term global warming within tolerable limits.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
This year's Oscar-nominated musicians are going to take the stage at the Academy Awards ceremony.
When Finnish programmer Jerry Jalava had a motorcycle accident in 2008, he faced a double tragedy. First, he lost his finger, an obvious problem for anyone who types for a living. Second, he had to deal with a medical team who thought they were comedians—learning of his profession, one surgeon joked that Jalava should go out and buy a “USB finger drive.”
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Beyoncé featuring Nicki Minaj “Flawless (Remix)” (Parkwood/Columbia)
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
5. The 2012 Ig Nobel Chemistry Prize
Length-scale dependence of protein hydration-shell density
In total, Chinese mainland has 54 institutions in the listing of top 300 universities in Asia.
One side of the capsized Eastern Star was rolled above water at 7:30 am Friday, as rescuers worked through the night to right the upturned ship in the Yangtze River. The side that has emerged shows "Eastern Star" in Chinese character on the hull.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Next year will be the 60th anniversary of the beloved talking bear. And to mark the occasion, Paul King, who directed 2014’s critical and commercial smash, simply titled Paddington, is back for this sequel. In a time where even children’s entertainments are suffused with darkness and violence, this quiet celebration of the everyday English is needed more than ever. The plot of this film? Well, not much really: following the events of the last film, Paddington is quite comfortably installed with the Brown family of Windsor Gardens. He wants to buy a pop-up book for his aunt from a local bookseller, but finding himself a few quid short he puts on his wellies and duffel coat and finds employment in various odd jobs – only to have the book stolen from the shop! A (not so serious) mystery begins. Expect many more jokes about Paddington’s love of marmalade. Released in the UK November 10, November 23 in Germany and November 30 in Cambodia and Malaysia. (Credit: StudioCanal)
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
HEC Paris and London Business School have tightened their grip on the top of the Financial Times rankings of pre-experience and post-experience Masters in Finance programmes respectively, having dominated the finance rankings since they were first published in 2011.
Song of the year: "Over you," Miranda Lambert and Blake Shelton
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